The other two drugs, forteo and miacalcin, require ...

-- Primary health physicians now have a new - and perhaps more convenient - a tool to combat osteoporosis bone disease. This week (FDA) has approved new drug Prolia (denosumab), contribute to bone strength and prevent fractures in postmenopausal women suffering from osteoporosis who are at high risk. high risk of fractures who have suffered fractures associated with osteoporosis or have had success with other methods of treatment of osteoporosis. Approximately half of all women over 50 will experience osteoporosis-related fracture in their lives, according to the National Institutes of Health. Prolia, the first drug of its kind osteoporosis, works by blocking the cell type that breaks down bone. Unlike most

drugs that are available in tablets or delivered through a skin patch, Prolia introduced doctor every six months. It is always good for doctors and patients to have more opportunities, said Dr. Ethel Siris, MD, Director, Center for Osteoporosis at Columbia University Medical Center in New York. This is a very powerful tool and it is quite clear that reducing the risk of fractures is quite reliable. Siris was one of the key researchers on the study of nearly 8000 postmenopausal women suffering from osteoporosis, which served as the basis for approval by FDA. For three years of study - funded by the drug manufacturer, Amgen - women who took Prolia less than placebo to test the spine, hip and other fractures. Approximately 2 percent of women under Prolia injured spine fracture, for example, compared with 7 percent in the placebo group. (Siris, a former president of the National Endowment for osteoporosis, served on paid advisory board of Amgen).

Prolia not the first injecting drug osteoporosis. Two bisphosphonates medication, Reclast and bonds, delivered intravenously in a doctor's office. The other two drugs, Forteo and Miacalcin, require self-injections every day and every day, respectively. Prolia is a new type of injectable drugs, however. This is the first biological agent to be approved for the treatment of osteoporosis. Biological products that are genetically modified versions of human proteins (rather than synthetic chemicals) are often used to treat conditions such as rheumatoid arthritis and psoriasis. Since no pills to remember to take, Prolia will that osteoporosis patients receive treatment and new drug may be easier than other options injection, said Siris. Reclast, for example, requires that doctors infusion chair in the office and requires a test for kidney problems before each dose. None of them is necessary to Prolia. The idea that I can, at the end of the visit, remove the syringe, swab some alcohol on muscle deltovydnoy patient, and do it myself, no nurse is attractive to me, she says. Prolia also will be the first biological sold directly to primary care physicians (excluding vaccines). Other biological agents used today in medicine, provided such experts as rheumatologists, endocrinologists, hematologists, oncologists, and, says Dr. Nancy Lane, MD, Director, Center for Healthy Aging at the University of California at Davis.

But mostly [osteoporosis] is interpreted primary care physicians. Thus, it will be injected into the doctor's office - as a flu shot. It is not clear whether Prolia stronger and more effective than existing drugs osteoporosis, says Lane. In clinical trials presented FDA, most side effects are different types of pain (including back pain), high cholesterol, as well as infections of the urinary bladder. Rare but more serious side effects, including reduction in blood calcium, infection, cellulitis skin infection and eczema. Prolia may also contribute to severe disease of bone (necrosis), which affects the jaw, FDA noted. Bone weakening target cells Prolia also play an important role in immunity, because the drug has the potential to affect several levels of the immune system, according buy lasix generic online to the FDA Center for drug evaluation and research. Also, do not know whether it is safe in patients taking other agents of biological, as in rheumatoid arthritis, says Lane. FDA requires patients who are considering Prolia get guide that explains the risks associated with drugs. Copyright.