The other two drugs, forteo and miacalcin, require ...

-- Primary health physicians now have a new - and perhaps more convenient - a tool to combat osteoporosis bone disease. This week (FDA) has approved new drug Prolia (denosumab), contribute to bone strength and prevent fractures in postmenopausal women suffering from osteoporosis who are at high risk. high risk of fractures who have suffered fractures associated with osteoporosis or have had success with other methods of treatment of osteoporosis. Approximately half of all women over 50 will experience osteoporosis-related fracture in their lives, according to the National Institutes of Health. Prolia, the first drug of its kind osteoporosis, works by blocking the cell type that breaks down bone. Unlike most

drugs that are available in tablets or delivered through a skin patch, Prolia introduced doctor every six months. It is always good for doctors and patients to have more opportunities, said Dr. Ethel Siris, MD, Director, Center for Osteoporosis at Columbia University Medical Center in New York. This is a very powerful tool and it is quite clear that reducing the risk of fractures is quite reliable. Siris was one of the key researchers on the study of nearly 8000 postmenopausal women suffering from osteoporosis, which served as the basis for approval by FDA. For three years of study - funded by the drug manufacturer, Amgen - women who took Prolia less than placebo to test the spine, hip and other fractures. Approximately 2 percent of women under Prolia injured spine fracture, for example, compared with 7 percent in the placebo group. (Siris, a former president of the National Endowment for osteoporosis, served on paid advisory board of Amgen).

Prolia not the first injecting drug osteoporosis. Two bisphosphonates medication, Reclast and bonds, delivered intravenously in a doctor's office. The other two drugs, Forteo and Miacalcin, require self-injections every day and every day, respectively. Prolia is a new type of injectable drugs, however. This is the first biological agent to be approved for the treatment of osteoporosis. Biological products that are genetically modified versions of human proteins (rather than synthetic chemicals) are often used to treat conditions such as rheumatoid arthritis and psoriasis. Since no pills to remember to take, Prolia will that osteoporosis patients receive treatment and new drug may be easier than other options injection, said Siris. Reclast, for example, requires that doctors infusion chair in the office and requires a test for kidney problems before each dose. None of them is necessary to Prolia. The idea that I can, at the end of the visit, remove the syringe, swab some alcohol on muscle deltovydnoy patient, and do it myself, no nurse is attractive to me, she says. Prolia also will be the first biological sold directly to primary care physicians (excluding vaccines). Other biological agents used today in medicine, provided such experts as rheumatologists, endocrinologists, hematologists, oncologists, and, says Dr. Nancy Lane, MD, Director, Center for Healthy Aging at the University of California at Davis.

But mostly [osteoporosis] is interpreted primary care physicians. Thus, it will be injected into the doctor's office - as a flu shot. It is not clear whether Prolia stronger and more effective than existing drugs osteoporosis, says Lane. In clinical trials presented FDA, most side effects are different types of pain (including back pain), high cholesterol, as well as infections of the urinary bladder. Rare but more serious side effects, including reduction in blood calcium, infection, cellulitis skin infection and eczema. Prolia may also contribute to severe disease of bone (necrosis), which affects the jaw, FDA noted. Bone weakening target cells Prolia also play an important role in immunity, because the drug has the potential to affect several levels of the immune system, according buy lasix generic online to the FDA Center for drug evaluation and research. Also, do not know whether it is safe in patients taking other agents of biological, as in rheumatoid arthritis, says Lane. FDA requires patients who are considering Prolia get guide that explains the risks associated with drugs. Copyright.

The fear of skin cancer

Osteoporosis

simply means weakening

bone: osteopenia can be considered mild, early stages of osteoporosis >>. << The most common cause of osteoporosis / osteopenia is

deficiency of vitamin D. In addition, in postmenopausal women, the loss of ovarian function

during menopause is another important cause of osteoporosis >>. << However, if a woman is surgical removal of ovaries in

young age, she is prone to osteoporosis at a young age. Some women experience premature

ovarian failure in the twenties or thirties

. So, these women also are at high risk of osteoporosis

at a young age. A. Deficiency of vitamin D

2. Menopause

3. Spontaneous absence of menstruation for more than 6 months (Pregnancy

exception). 4. Low testosterone levels in men

5. Hyperactivity >>

<< thyroid 6. Hyperactivity parathyroid glands (4 glands, which lie only

behind the thyroid gland in the neck)

7. Some gastrointestinal disorders

8. Some medications such as prednisone, Dilantin and the thyroid hormones

in excessive doses. 9. Excessive leakage of calcium from the kidneys, rare >> << state. is the most common cause >> << osteoporosis in men and women. Unfortunately, vitamin D deficiency remains unrevealed to most people. The main natural source of vitamin D is sun. The fear of skin cancer

and private life led to the epidemic deficiency of vitamin D. Even worse things in the sanatorium patients, patients with malabsorption syndrome

and patients on certain medications such as

Dilantin and steroids. Another common cause >> << osteoporosis in women. Most women have low vitamin D

when they reach menopause. Then they get hit by lack of estrogen:

, double blow! in men, is a frequent cause of osteoporosis. Other causes of osteoporosis >> << men and women include: taking medications for the treatment of thyroid disorder or

. If you treat the thyroid gland is very

important to test thyroid function (blood test) done on >> << regularly. Your doctor will recommend changes in dose

thyroid hormones based on tests of thyroid function. Note that

in many patients with thyroid cancer, thyroid hormones intentionally

in large doses to prevent a recurrence of cancer. In such cases,

, the measures taken to prevent or reduce bone loss should be

discussed with a physician, preferably an endocrinologist. Such as prednisone, which when used in a daily dose of more than

7. 5 mg for more than a few weeks, can lead to significant loss of bone tissue. Another common cause of osteoporosis, which is usually found

the way to a regular blood test that indicates a high level of calcium. (Idiopathic renal calcium leak) is

rare condition that can lead to osteoporosis. In the U.S., osteoporosis is often diagnosed using >> << widely available test called drive (dual energy x-ray absorbtsiometrii)

test. It is important to note that the reliability of this test depends on >> << techniques. Interpretation of test you need a doctor

knowledge of osteoporosis, such as an endocrinologist, a rheumatologist

or radiologist. So do your homework and use a decent place to go

this test. Testing bone density

available in most hospitals in the United States. Repeat testing in 1-2 years should be done in >> << the same place, using the same machine in order to monitor effects of therapy >>. << Who should have a bone density test done? A. Anyone with raw deficiency of vitamin D. 2. In postmenopausal women. 3. Men with low testosterone

4. Not on

prednisone, Dilantin, or excessive thyroid hormone. 5. Anyone with

untreated overactive thyroid (hyperthyroidism). 6. Anyone with

untreated thyroid hyperactivity parathyroid glands. 7. Anyone with absence of menstruation for more

6 months (excluding pregnancy). Need more tests

in addition to bone density test? Yes. Bone density test can only

diagnose whether you have osteoporosis. The next step is to find out why >> << osteoporosis. Vitamin D deficiency is the most common cause of osteoporosis. In most in postmenopausal women, estrogen deficiency

and vitamin D, deficiency is a major cause of osteoporosis >>. Other reasons << osteoporosis should be investigated

as many of these reasons, such as overactive thyroid and parathyroid glands

usually not clinically apparent. Therefore

special laboratory tests should be done to diagnose these conditions. Osteoporosis in men is usually found

by the way, such as detection of pathologic fractures (fractures

virtually nothing the injury) with ribs, hips or spine on the X-ray for

other reasons. To determine the degree of bone loss, bone density measurements

is usually bone test DEXA. The corresponding >> << testing should be done to determine the cause of osteoporosis, as

, treatment will depend on the cause identified in a patient >>. << Treatment of osteoporosis depends on its main reason >>. << This is why it is important to determine the exact cause of osteoporosis >>. << Most patients with osteoporosis, vitamin D and calcium

in appropriate doses is an important part of treatment. People who are on long-term

steroids (eg prednisone or hydrocortisone) or

Dilantin, Vitamin D replacement is even more important. Avoid excessive thyroid hormone when it is done intentionally, as in

patients with thyroid cancer. Hyperactivity buy lasix 100 mg thyroid disease, such as should be properly treated endocrinologist >>. << Indeed, consider parathyroid surgery. Drugs

for the treatment of osteoporosis in the U.S.:

1. Fosamax (alendronate)

2. Actonal (ryzedronat)

3. Boniva (Ibandronat)

4. Evista (raloksifen)

5. 6. Miacalcin (calcitonin) nasal spray

7. Estrogen

therapy, testosterone therapy in men with low testosterone >>. << 8. (Sold under the brand name Zometa,

Zomera,

Aclasta and Reclast Fosamax, Actonel, Boniva and zoledronovoyi acids belong to a class of drugs known as bisphosphonates

. 9. Are newly eligible to use anti- -osteoporosis drugs. Each anti-osteoporosis drug has possible side effects that you should

discuss with your doctor before you go to any of these drugs. This article was written by Sarfraz Zayed, MD, FACE. Doctor Zayed

specializes in diabetes, endocrinology

and Metabolism. Dr. Zayed is Assistant Professor of Clinical Medicine in Los Angeles and director of the Diabetes

Jamila and Endocrine Medical Center a thousand

Oaks, California. Copyright © 1999-2011 All rights reserved.

Although the balance 50mh/ml bottle dosage came

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